Important Information
If you are interested in applying for this study, please:
如果您有兴趣申请参与本研究，请仔细阅读以下内容：点击此链接
本試験への参加をご希望の方は: こちらをクリックしてください。
- Read the study description and study information document.
- Review the Visit Planner dates in your location and confirm that you are available for the stated dates.
- Complete the registration form below.
We will then contact you to check your suitability.
Study Information
New Zealand Clinical Research is trialling an investigational medicine that could help people with a liver disease called metabolic dysfunction-associated steatohepatitis (MASH).
MASH is a type of fatty liver disease that can cause inflammation and damage to the liver over time. Without proper treatment, MASH can lead to liver scarring and eventually liver cancer.
The investigational medicine, efimosfermin, is based on a natural hormone in the body that helps regulate energy use and protect the liver. It works by reducing fat in the liver, lowering inflammation, and preventing scarring. Because the natural hormone doesn’t stay in the body for long, efimosfermin is designed to last longer and work more effectively. Previous studies suggest that treatments like this may improve liver health in people with MASH.
This is a clinical trial, and we are looking for healthy volunteers of [White/European] [Chinese] [Japanese] descent to support the research.
Requirements
Healthy NZ European, Chinese, and Japanese Males and Females
-
- Aged between 18 – 55 years
- Weigh 50+ kgs (males) or 45+ kgs (females)
- BMI (Body Mass Index) between 18 – 28 kg/m2
- Non-smokers/vapers or Ex-smokers/vapers allowed
- Not currently taking any regular prescription medications or supplements. Certain prescription medications including contraceptives are allowed in the study.
- Meets contraception requirements
- Must meet the ancestry criteria of:
- Chinese Cohort [1]
- Be of Chinese Ancestry
- Born in mainland China, Hong Kong, or Taiwan
- Both parents and all 4 grandparents are ethnically Chinese
- Have lived outside China, Hong Kong, or Taiwan for less than 10 years
- Japanese Cohort [2]:
- Be of Japanese Ancestry
- Born in Japan
- Both parents and all 4 grandparents are ethnically Japanese
- Have lived outside Japan for less than 10 years
- European Cohort [3]:
- Be of White/European Ancestry
- Both parents and all 4 grandparents are of White/European ancestry
- Chinese Cohort [1]
What is Involved?
Study Visits: 6 [7] night stay + 6 visits
Reimbursement: Up to $5,000 before tax